Ones that are taxane- or epithilone-resistant.","extract_html":"

Taccalonolides are

The Lucaci Church is a Romanian Orthodox church located at 6 Logofăt Udriște Street in Bucharest, Romania. It is dedicated to Saints Nicholas and Stylianos.

Taccalonolides are a class of microtubule-stabilizing agents isolated from Tacca chantrieri that has been shown to have selective cancer-fighting properties. Other examples of microtubule-stabilizing agents include taxanes and epothilones, both of which prevent cancer cells from dividing by interfering with tubulin. While taxanes like paclitaxel and docetaxel have been used successfully against breast, ovarian, prostate, and non–small-cell lung cancers, intrinsic and acquired drug resistance limit their anticancer properties. Unlike taxanes, taccalonolides appear to work through a different mechanism of action that does not involve tubulin, although recently isolated taccalonolides AF and AJ have shown tubulin-interaction activity. The discovery of taccalonolides opens up new possibilities to treat cancer cells, especially ones that are taxane- or epithilone-resistant.

Lee Majors is an American actor. He portrayed the characters of Heath Barkley on the American television Western series The Big Valley (1965–1969), Colonel Steve Austin on the American television science-fiction action series The Six Million Dollar Man (1973–1978), and Colt Seavers on the American television action series The Fall Guy (1981–1986).